Angel Cisneros

PhD Student / Protein-protein interaction
e-mail:
angel-fernando.cisneros-caballero.1 [at] ulaval.ca

Biography

Ever since I was young, I have been highly curious and willing to learn about different areas in science. Throughout my undergraduate degree in Biotechnological Engineering at the Monterrey Institute of Technology and Higher Education in Mexico City, I participated in several internships in different Mexican research institutes, namely the National Institute for Respiratory Diseases, the National Institute of Genomic Medicine, and the National Institute of Psychiatry, as well as the Institut de Biologie Intégrative et des Systèmes in Québec City. Working in different laboratories led me to develop interdisciplinary skills and introduced me to the field of bioinformatics, which I believe will continue to develop at a very accelerated pace and allow for an increased understanding of biological processes. I finished my undergraduate degree in December 2016, and then I decided to return to Québec City to continue working in Christian Landry’s laboratory. In September 2017, I started a Master’s Degree in Biochemistry with a concentration in Bioinformatics at Laval University. In May 2019, I advanced to a PhD in Biochemistry, still in Christian’s laboratory.

 

Research interests

How do proteins interact? How and why are particular interfaces selected over others? My current project at the Landry lab aims to use an interface-based approach to the study of protein interactions among homologs. I am interested in looking for patterns in the amino acid sequence of monomers and crystallographic structures that would allow me to better understand how protein interactions between paralogs and orthologs diverge.

Publications

Cisneros AF*, Gagnon-Arsenault I*, Dubé AKD, Després PC, Kumar P, Lafontaine K, Pelettier JN, and Landry CR. Epistasis between promoter activity and coding-mutations shapes gene evolvability. Science Advances, 9.5: eadd9109 (2023) 

Bédard C*, Cisneros AF*, Jordan D, and Landry CR. Correlation between protein abundance and sequence conservation: what do recent experiments say? Current Opinion in Genetics and Development, 77 (2022) 

Després PC, Cisneros AF, Alexander EMM, Sonigara R, Gagné-Thivierge C, Dubé AK, and Landry CR. Asymmetrical dose responses shape the evolutionary trade-off between antifungal resistance and nutrient use. Nature Ecol Evol (2022) 

Gama Braga L, Cisneros A, Mathieu M, Clerc M, Garcia P, Lottin B, Garand C, Thebault P, Landry CR, & Elowe S. The BUBR1 pseudokinase domain promotes efficient kinetochore PP2A-B56 recruitment to regulate spindle checkpoint silencing and chromosome alignmentCell Reports 33 (7), 108397 (2020)

Hallin J, Cisneros A, Hénault M, Fijarczyk A, Dandage R, Bautista C, & Landry CR. Similarities in biological processes can be used to bridge ecology and molecular biology. Evolutionary Applications 13 (6), 1335-1350 (2020).

Martiñon S, Cisneros A, Villicaña S, Hernández-Miramontes R, Mixcoha E, & Calderón-Vargas P, Chemical and Immunological Characteristics of Aluminum-Based, Oil-Water Emulsion, and Bacterial-Origin Adjuvants. Journal of Immunology Research 2019: 3974127 (2019)

Marchant A*, Cisneros A*, Dubé A, Gagnon-Arsenault I, Ascencio D, Jain H, Aubé S, Eberlein C, Evans-Yamamoto D, Yachie N & Landry C, The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs. eLife 8: e46754 (2019)

Cisneros A, Felgueres M, Vela E & Gómez D, Estrategias terapéuticas para la artritis reumatoide: hacia las terapias biotecnológicas. Investigación en Discapacidad 6:69-87 (2017)