Pascale Lemieux
PhD Student / Evolutionary systems biology
e-mail: pascale.lemieux.4 [at] ulaval.ca
Biography
Since a young age, I was very curious about the science behind natural phenomena. Growing up, I went to a summer camp in Charlevoix focused on ecology and astronomy and ended up working there 2 summers. This is where I decided I wanted to know more about the inner mechanisms of life. Thus, I moved to Quebec City to pursue a degree in Biochemistry at Université Laval (2017-2020). At the end of my first year, I had my first internship at the Molecular Tools Platform where I learned about molecular biology and genetic engineering. It was for my second internship that I joined the Landry Lab. I continued my academic career in the Landry Lab with a Master’s degree (2020-2022) followed by a PhD also in Biochemistry (2022-).
Research interests
From my internship in the Landry Lab, I like the idea that we can modify cells to optimize them for a specific function which is the basic principle of bioengineering. My PhD project is focused on the characterization of synthetic scaffolds using protein-protein interaction as the colocalization mechanism. This project is the combination of my curiosity for the interactome evolution, which was the subject of my Master degree, and my interest in bioengineering.
Publications
Lemieux P, Bradley D, Dissection of the role of a SH3 domain in the evolution of binding preference of paralogous proteins. Genetics, iyad175 , Dionne U, and Landry CR. (2023)
Cisneros AF*, Rouleau F*, Bautista C, Lemieux P, Dumont-Leblond N. Toeholder: a software for automated design and in silico validation of toehold riboswitches. PeerJ Physical Chemistry 5:e28 (2023)
Plante S, Moon KM, Lemieux P, Foster LJ, and Landry CR. Breaking spore dormancy in budding yeast transforms the cytoplasm and the solubility of the proteome. PLOS Biology 21(4): e3002042 (2023)