Marie-Ève Picard, PhD
Postdoctoral fellow / Antifungal resistance e-mail: marie-eve.picard.8 [at] ulaval.ca
Biography
I completed my undergraduate studies in Biochemistry at Université Laval (2011–2014), where I first joined the laboratory of Dr. Rong Shi as a summer intern. I continued my graduate studies in the same lab, earning both my Master’s and PhD degrees in Biochemistry co-directed with Dr. Michel Cusson (National Resources Canada). My doctoral research focused on the structural biology of insect enzymes involved in the juvenile hormone biosynthesis pathway, a process important for insect development and reproduction, with the spruce budworm as the primary species studied. I first became involved with the Landry Lab through a project exploring how gene duplication and compensatory mutations can enable constructive neutral evolution. As part of this work, protein structures were determined by X-ray crystallography to understand how deleterious mutations in homodimers could be buffered through heteromer formation.
Research interests
I am interested in understanding how antimicrobial resistance evolves at the molecular level, with a particular focus on protein structure and function, and how mutations in resistance proteins affect their activity and drug susceptibility across species.
Publications

Després PC, Dubé AK, Picard ME, Grenier J, Shi R, and Landry CR. Compensatory mutations potentiate constructive neutral evolution by gene duplication. Science 385 (6710), 770-775 (2024)