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Isabelle Gagnon-Arsenault, PhD 

Research professional / Lab manager
e-mail: isabelle.gagnon-arsenault.1 [at] ulaval.ca

Biography

I obtained a master’s and a doctorate’s degree in the laboratory of Dr. Yves Bourbonnais at Université Laval and I am now specialized with the use of the yeast Saccharomyces cerevisiae as a working tool and as a model organism. Being easy to manipulate genetically, this single-celled organism allows us to try to answer many scientific questions of interest for the laboratory. My work in the laboratory of Dr. Christian Landry can be divided into three parts (administration, instrumentation and experimentation) which are making me a resource person (commonly named “the mom of the lab”) for students and researchers.

 

Publications

Evans-Yamamoto D*, Dubé AK*, Saha G*, Plante S, Bradley D, Gagnon-Arsenault I, and Landry CR. Parallel nonfunctionalization of CK1δ/ε kinase ohnologs following a whole-genome duplication event. Molecular Biology and Evolution, msad246 (2023) 

Biot-Pelletier D, Bettinazzi S, Gagnon-Arsenault I, Dubé AKD, Bédard C, Nguyen THM, Fiumera HL, Breton S, and Landry CR. Evolutionary trajectories are contingent on mitonuclear interactions. Molecular Biology and Evolution, Volume 40, Issue 4, msad061 (2023) 

Cisneros AF*, Gagnon-Arsenault I*, Dubé AKD, Després PC, Kumar P, Lafontaine K, Pelettier JN, and Landry CR. Epistasis between promoter activity and coding-mutations shapes gene evolvability. Science Advances, 9.5: eadd9109 (2023) 

Ascencio D, Diss G, Gagnon-Arsenault I, Dubé AK, DeLuna A, & Landry CR, Expression attenuation as a mechanism of robustness against gene duplication. PNAS 118 (6) (2021)

Dandage R*, Berger CM*,  Gagnon-Arsenault I, Moon KM, Stacey RG, Foster LJ, & Landry CR. Frequent Assembly of Chimeric Complexes in the Protein Interaction Network of an Interspecies Yeast Hybrid  Molecular Biology and Evolution (2020).

Marchant A, Cisneros A, Dubé A, Gagnon-Arsenault I, Ascencio D, Jain H, Aubé S, Eberlein C, Evans-Yamamoto D, Yachie N & Landry C, The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs. eLife 8: e46754 (2019)

Bleuven C, Dubé AK, Nguyen GQ, Gagnon-Arsenault I, Martin H, and Landry CR, A collection of barcoded natural isolates of Saccharomyces paradoxus to study microbial evolutionary ecology. MicrobiologyOpen 8 (7), e00773 (2019)

Durand E, Gagnon-Arsenault I, Hallin J, Hatin I, Dubé A, Nielly-Thibault L, Namy O and Landry C, Turnover of ribosome-associated transcripts from de novo ORFs produces gene-like characteristics available for de novo gene emergence in wild yeast populations. Genome Research 29 (6), 932-943 (2019)

Chrétien AE, Gagnon-Arsenault I, Dubé AK, Barbeau X, Després PC, Lamothe C, Dion-Côté AM, Lagüe P & Landry CR, Extended linkers improve the detection of protein-protein interactions (PPIs) by dihydrofolate reductase protein-fragment complementation assay (DHFR PCA) in living cells. Molecular & Cellular Proteomics 17:373-383 (2018)

Samandi S, Roy AV, Delcourt V, Lucier JF, Gagnon J, Beaudoin MC, Vanderperre B, Breton MA, Motard J, Jacques JF, Brunelle M, Gagnon-Arsenault I, Fournier I, Ouangraoua A, Hunting DJ, Cohen AA, Landry CR, Scott MS & Roucou X, Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins. eLife 6:e27860 (2017)

Diss G, Gagnon-Arsenault I, Dion-Coté AM, Vignaud H, Ascencio DI, Berger CM & Landry CR, Gene duplication can impart fragility, not robustness, in the yeast protein interaction network. Science 355:630-634 (2017)

Filteau M, Hamel V, Pouliot MC, Dubé AK, Gagnon-Arsenault I & Landry CR, Evolutionary rescue by compensatory mutations is constrained by genomic and environmental backgrounds. Molecular Systems Biology 11:832 (2015)

Filteau M, Diss G, Torres-Quiroz F, Dube AK, Schraffl A, Bachmann V, Gagnon-Arsenault I, Chretien AE, Steunou AL, Dionne U, Coté J, Bisson N, Stefan E & Landry CR, Systematic identification of signal integration by Protein Kinase A. PNAS 112:4501-4506 (2015)

Nguyen Ba AN, Strome B, Hua JJ, Desmond J, Gagnon-Arsenault I, Weiss EL, Landry CR & Moses AM, Detecting functional divergence after gene duplication through evolutionary changes in posttranslational regulatory sequences. PLoS Computational Biology 12:e1003977 (2014)

Rochette S, Gagnon-Arsenault I, Diss G & Landry CR Modulation of the yeast protein interactome in response to DNA damage. Journal of Proteomics 100:25-36 (2014)

Diss G, Dubé AK, Boutin J, Gagnon-Arsenault I, & Landry CR, A systematic approach for the genetic dissection of protein complexes in living cells. Cell Reports 3:2155–2167 (2013) See also Nature Methods 10:821 (2013)

Gagnon-Arsenault I, Marois Blanchet FC, Rochette S, Diss G, Dube AK & Landry CR, Transcriptional divergence plays a role in the rewiring of protein interaction networks after gene duplication. Journal of Proteomics 81:112-125 (2013)

Leducq JB, Charron G, Diss G, Gagnon-Arsenault I, Dubé AK & Landry CR, Evidence for the robustness of protein complexes to inter-species hybridization. PLoS Genetics 8:e1003161 (2012)

Isabelle Gagnon-Arsenault I, Parisé L, Tremblay J & Bourbonnais Y, Activation mechanism, functional role and shedding of glycosylphosphatidylinositol-anchored Yps1p at the Saccharomyces cerevisiae cell surface. Molecular Microbiology 69:982-993 (2008)

Isabelle Gagnon-Arsenault I, Tremblay J & Bourbonnais Y, Fungal yapsins and cell wall: a unique family of aspartic peptidases for a distinctive cellular function. FEMS Yeast Research 6:966-978 (2006)

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