Rohan Dandage, PhD 

Postdoctoral fellow / Evolutionary systems biology
rohan.dandage.1 [at]


Pursuing my interest in biology, I studied biotechnology for my Bachelor’s (2010, in Pune) and Master’s degree (2012, in New Delhi). Then, I delved into “proper” research during my Ph.D at the Institute of Genomics and Integrative Biology, New Delhi (2018). There, I worked on biophysical aspects of chemical chaperone-assisted protein folding and investigated molecular constraints of molecular evolution. Thereon, I started my postdoc in evolutionary systems biology with Christian’s team (in beautiful Québec City). Here, I am investigating evolution of protein-protein interactions through gene editing and yeast genetics. My areas of expertise are molecular biology, computational biology and chemical biology.


Research interests

Broadly, I am interested in understanding how complex adaptive systems work. During my postdoc, I mainly focus on protein-protein interactions, which constitute a central complex adaptive system within the cell. Among protein-protein interactions, phospho-protein networks are of utmost importance owing to their fundamental role in almost all the functionalities of a cell. In order to understand fidelity within the phospho-protein networks, I will carry out network perturbations using CRISPR-based gene editing and monitor contributions of correct and mis-interactions towards cellular fitness. Alongside, I am also looking for ways to characterize edgotypic variants of unknown significance (VUS), in a high throughput manner.


Dionne U, Bourgault E*, Dubé AK*, Bradley D*, Chartier FJM*, Dandage R, Dibyachintan S, Després PC, Gish GD, Hang Pham NT, Létourneau M, Lambert JP, Doucet N, Bisson N, and Landry CR. Protein context shapes the specificity of SH3 domain-mediated interactions in vivo. Nature Communications 12, 1597 (2021)

Dandage R*, Berger CM*,  Gagnon-Arsenault I, Moon KM, Stacey RG, Foster LJ, & Landry CR. Frequent Assembly of Chimeric Complexes in the Protein Interaction Network of an Interspecies Yeast HybridMolecular Biology and Evolution (2020)

Hallin J, Cisneros AF, Hénault M, Fijarczyk A, Dandage R, Bautista C, & Landry CR.  Similarities in biological processes can be used to bridge ecology and molecular biology. Evolutionary Applications 13 (6), 1335-1350 (2020)

Dandage R, Landry CR. Paralog dependency indirectly affects the robustness of human cells. Molecular Systems Biology 15 (9), e8871 (2019)

Dandage R, Després PC, Yachie N & CR Landry, beditor: A computational workflow for designing libraries of guide RNAs for CRISPR base editing. Genetics 212 (2), 377-385 (2019)

Dandage R, Pandey R, Jayaraj GG, Rai M & Chakraborty K, Differential strengths of molecular determinants guide environment specific mutational fates. PLOS Genetics 14:e1007419 (2018)

Dandage R & Chakraborty K, dms2dfe : Comprehensive workflow for analysis of deep mutational scanning data. The Journal of Open Source Software 2:362-364 (2017)

Dandage R, Bandyopadhyay A, Jayaraj GG, Saxena K, Dalal V, Das A R & Chakraborty K, Classification of chemical chaperones based on their effect on protein folding landscapes. ACS Chemical Biology 10:813-820 (2015)