Lou N-T – bio

English

Lou Nielly-Thibault 

PhD student
Bioinformatics and evolutionary genomics

Biography

I have been a PhD student in biology in the Landry lab since January 2017. I did my undergraduate training in biochemistry at Laval University, during which I started in research as an intern and assistant in the Landry lab. Since then, I have been acquiring bioinformatic skills to complement my studies in biochemistry, and my research activities have been mostly bioinformatic and theoretical. After receiving my bachelor’s degree, I undertook a master’s degree in biology in the Landry lab. One year later, I did an accelerated transition to the biology PhD program, thereby expanding my master’s project into a PhD project.

Research interests

My PhD is about the emergence of new protein-coding genes from non-coding DNA during evolution. I am especially interested in identifying the various factors that determine the properties of these new genes at the time of their “birth”. More generally, I like to study the mechanisms which explain the evolution (and thus the current structure) of genomes and the molecules that they produce. My favorite tools for this endeavor are programming and probability theory.

Publications

Hénault M*, Eberlein C*, Charron G, Durand E, Nielly-Thibault L, Martin H & Landry CR, Yeast population genomics goes wild: the case of Saccharomyces paradoxus. In: Polz M, Rajora OP (eds) Population genomics: microorganisms. Springer, Cham (2017)

Eberlein C, Nielly-Thibault L, Maaroufi H, Dubé AK, Leducq JB, Charron G & Landry CR, The rapid evolution of an ohnolog contributes to the ecological specialization of incipient yeast species. Molecular Biology and Evolution 34:2173-2186 (2017)

Leducq JB*, Henault M*, Charron G, Nielly-Thibault L, Terrat Y, Fiumera HL, Shapiro BJ & Landry CR, Mitochondrial recombination and introgression during speciation by hybridization. Molecular Biology and Evolution 34:1947-1959 (2017)

Xia W, Nielly-Thibault L, Charron G, Landry CR, Kasimer D, Anderson JB & Kohn LM, Population genomics reveals structure at the individual, host-tree scale and persistence of genotypic variants of the undomesticated yeast Saccharomyces paradoxus in a natural woodland. Molecular Ecology 26:995–1007 (2017)

Barbosa R, Almeida P, Safar SVB, Santos RO, Morais PB, Nielly-Thibault L, Leducq JB, Landry CR, Gonçalves P, Rosa CA & Sampaio JP, Evidence of natural hybridization in Brazilian wild lineages of Saccharomyces cerevisiae. Genome Biology and Evolution 18:317–329 (2016)

Leducq JB*, Nielly-Thibault L*, Charron G*, Eberlein C, Verta JP, Samani P, Sylvester K, Hittinger CT, Bell G & Landry CR, Speciation driven by hybridization and chromosomal plasticity in a wild yeast. Nature Microbiology 1:15003 (2016)

Landry CR, Zhong X, Nielly-Thibault L & Roucou X, Found in translation: functions and evolution of a recently discovered alternative proteome. Current Opinion in Structural Biology 32:74–80 (2015)

Français

Lou Nielly-Thibault

Etudiant au Doctorat
Bioinformatique et génomique évolutive

Biographie

Je suis étudiant au doctorat en biologie dans le labo Landry depuis janvier 2017. J’ai effectué un baccalauréat en biochimie à l’Université Laval, durant lequel j’ai fait mes débuts en recherche en tant que stagiaire et auxiliaire dans le labo Landry. Dès lors, j’ai entrepris d’acquérir des compétences complémentaires à ma formation en biochimie, et mes activités de recherche sont principalement de natures bio-informatique et théorique. Après avoir obtenu mon diplôme de baccalauréat, j’ai entrepris une maîtrise en biologie dans le labo Landry. Un an plus tard, j’ai effectué un passage accéléré au doctorat en biologie, élargissant ainsi mon projet de maîtrise en un projet de doctorat.

Intérêts de recherche

Mon doctorat porte sur la transformation de l’ADN non codant en nouveaux gènes codant pour des protéines au fil de l’évolution. Je m’intéresse particulièrement à identifier les différents facteurs qui déterminent les propriétés de ces nouveaux gènes au moment de leur “naissance”. Plus généralement, j’aime étudier les mécanismes qui expliquent l’évolution (et donc la structure actuelle) des génomes et des molécules qu’ils produisent. Mes outils préférés pour y arriver sont la programmation et la théorie des probabilités.

Publications

Hénault M*, Eberlein C*, Charron G, Durand E, Nielly-Thibault L, Martin H & Landry CR, Yeast population genomics goes wild: the case of Saccharomyces paradoxus. In: Polz M, Rajora OP (eds) Population genomics: microorganisms. Springer, Cham (2017)

Eberlein C, Nielly-Thibault L, Maaroufi H, Dubé AK, Leducq JB, Charron G & Landry CR, The rapid evolution of an ohnolog contributes to the ecological specialization of incipient yeast species. Molecular Biology and Evolution 34:2173-2186 (2017)

Leducq JB*, Henault M*, Charron G, Nielly-Thibault L, Terrat Y, Fiumera HL, Shapiro BJ & Landry CR, Mitochondrial recombination and introgression during speciation by hybridization. Molecular Biology and Evolution 34:1947-1959 (2017)

Xia W, Nielly-Thibault L, Charron G, Landry CR, Kasimer D, Anderson JB & Kohn LM, Population genomics reveals structure at the individual, host-tree scale and persistence of genotypic variants of the undomesticated yeast Saccharomyces paradoxus in a natural woodland. Molecular Ecology 26:995–1007 (2017)

Barbosa R, Almeida P, Safar SVB, Santos RO, Morais PB, Nielly-Thibault L, Leducq JB, Landry CR, Gonçalves P, Rosa CA & Sampaio JP, Evidence of natural hybridization in Brazilian wild lineages of Saccharomyces cerevisiae. Genome Biology and Evolution 18:317–329 (2016)

Leducq JB*, Nielly-Thibault L*, Charron G*, Eberlein C, Verta JP, Samani P, Sylvester K, Hittinger CT, Bell G & Landry CR, Speciation driven by hybridization and chromosomal plasticity in a wild yeast. Nature Microbiology 1:15003 (2016)

Landry CR, Zhong X, Nielly-Thibault L & Roucou X, Found in translation: functions and evolution of a recently discovered alternative proteome. Current Opinion in Structural Biology 32:74–80 (2015)