Guillaume C – bio

English

Guillaume Charron 

PhD student
Yeast ecological genomics

Biography

In 2007 I obtained a college degree in biotechnologies in my hometown of Sherbrooke. I was first exposed to research during my internship where I worked at the Agriculture Canada’s R&D on the dairy bovine and pig center. After my collegial studies I decided to pursue a career in the biotech industry. I moved to Québec in August 2007 to work as a lab technician in a small biotech company which was producing yeasts for specific applications. After 2 years during which I had the impression I was not used to the full extent of my potential, I decide to go back to school in a domain I am very fond of, microbiology. I had the chance to join Christian’s Lab after answering a mail which Christian sent to recruit interns for the winter semester. I started in 2011 and I am still here, but as a graduate student! Since then, I participated in the discovery of the wild Saccharomyces paradoxus system, system that I have been studying since the beginning of my master’s degree to better understand speciation, reproductive isolation and hybridization. I hope to finish my PhD next year (around Fall 2018) and then pursue new directions, goals and challenges with the new knowledge I acquired during the last 7 years!

Research interests

I am particularly interested by everything that touches on speciation, more specifically hybrid speciation. I also have some interests in reproductive isolation mechanisms and their influence either by their presence or absence on the evolution of species. As a microbiologist I also like microbial ecology, notably the role that could have interspecies interactions in speciation. For sure, my research would be nothing without the power of the tools I use, which are based on the principles of microbiology, molecular biology and genetics. Also, I would love to discover new species!

Publications

Wolters JF, Charron G, Gaspary A, Landry CR, Fiumera AC & Fiumera HI, Mitochondrial recombination reveals mito-mito epistasis in yeast. Genetics doi: 10.1534/genetics.117.300660 (2018)

Hénault M*, Eberlein C*, Charron G, Durand E, Nielly-Thibault L, Martin H & Landry CR, Yeast population genomics goes wild: the case of Saccharomyces paradoxus. In: Polz M, Rajora OP (eds) Population genomics: microorganisms. Springer, Cham (2017)

Leducq JB*, Henault M*, Charron G, Nielly-Thibault L, Terrat Y, Fiumera HL, Shapiro BJ & Landry CR, Mitochondrial recombination and introgression during speciation by hybridization. Molecular Biology and Evolution 34:1947-1959 (2017)

Eberlein C, Nielly-Thibault L, Maaroufi H, Dubé AK, Leducq JB, Charron G & Landry CR, The rapid evolution of an ohnolog contributes to the ecological specialization of incipient yeast species. Molecular Biology and Evolution 34:2173-2186 (2017)

Charron G & Landry CR, No evidence for extrinsic post-zygotic isolation in a wild Saccharomyces yeast system. Biology Letters 13:20170197 (2017)

Peris D, Moriarty RV, Alexander WG, Baker EC, Sylvester K, Sardi M, Langdon QK, Libkind D, Wang QM, Bai FY, Leducq JB, Charron G, Landry CR, Sampaio JP, Gonçalves P, Hyma KE, Fay JC, Sato TK & Hittinger CT, Hybridization and adaptive evolution of diverse Saccharomyces species for cellulosic biofuel production. Biotechnology for Biofuels 10:78 (2017)

Xia W, Nielly-Thibault L, Charron G, Landry CR, Kasimer D, Anderson JB & Kohn LM, Population genomics reveals structure at the individual, host-tree scale and persistence of genotypic variants of the undomesticated yeast Saccharomyces paradoxus in a natural woodland. Molecular Ecology 26:995–1007 (2017)

Filteau M, Charron G & Landry CR, Identification of the fitness determinants of budding yeast on a natural substrate. The ISME Journal 11:959–971 (2016)

Peris D, Langdon QK, Moriarty RV, Sylvester K, Bontrager M, Charron G, Leducq JB, Landry CR, Libkind D & Hittinger CT, Complex ancestries of lager-brewing hybrids were shaped by standing variation in the wild yeast Saccharomyces eubayanus. PLoS Genetics 12:e1006155 (2016)

Leducq JB, Nielly-Thibault L, Charron G, Eberlein C, Verta JP, Samani P, Sylvester K, Hittinger CT, Bell G & Landry CR, Speciation driven by hybridization and chromosomal plasticity in a wild yeast. Nature Microbiology 1:15003 (2016)

Freel K, Charron G, Leducq JB, Landry CR & Schacherer J, Lachancea quebecensis sp. nov., a yeast species consistently isolated from the tree bark in the Canadian province of Quebec. International Journal of Systematic and Evolutionary Microbiology 65:3392-3399 (2015)

Charron G*, Leducq JB* & Landry CR, Chromosomal variation segregates within incipient species and correlates with reproductive isolation. Molecular Ecology 23:4362-4372 (2014)

Leducq JB*, Charron G*, Samani P, Dubé AK, Sylvester K, James B, Almeida P, Sampaio JP, Hittinger CT, Bell G & Landry CR, Local climatic adaptation in a widespread microorganism. Proceedings of the Royal Society B 281:20132472 (2014)

Charron G, Leducq JB, Bertin C, Dubé AK & Landry CR, Exploring the northern limit of the distribution of Saccharomyces cerevisiae and Saccharomyces paradoxus in North America. FEMS Yeast Research 14:281-288 (2014)

Leducq JB, Charron G, Diss G, Gagnon-Arsenault I, Dubé AK & Landry CR, Evidence for the robustness of protein complexes to inter-species hybridization. PLoS Genetics 8:e1003161 (2012)

Français

Guillaume Charron

Etudiant au Doctorat
Ecologie génomique de la levure

Biographie

Originaire de Sherbrooke, j’ai obtenu mon DEC en techniques de laboratoire : Biotechnologies en 2007 au cégep de Sherbrooke. C’est lors de mon stage que j’ai eu un premier contact avec la recherche en travaillant au centre de recherche et développement sur le bovin laitier et le porc d’Agriculture Canada. Après mes études collégiales, j’ai décidé de poursuivre une carrière en industrie. Je me suis dirigé vers Québec en août 2007 pour travailler en tant que technicien de laboratoire dans une petite compagnie de biotechnologies qui menait des activités de production de levures pour des applications spécifiques. Après 2 ans de travail où j’ai eu l’impression de ne pas être utilisé à mon plein potentiel, j’ai décidé de retourner sur les bancs d’écoles dans le but approfondir mes connaissances dans un domaine que j’apprécie beaucoup, la microbiologie. C’est en répondant à un courriel de Christian, qui cherchait des étudiants pour travailler dans son laboratoire, que j’ai eu la chance de joindre le laboratoire. J’ai commencé comme auxiliaire à l’hiver 2011 et j’y suis toujours, maintenant en tant qu’étudiant gradué ! Depuis ce temps, j’ai participé à la découverte du système des levures Saccharomyces paradoxus sauvages, système qui est celui que j’étudie depuis ma maitrise afin de mieux comprendre divers aspects de la spéciation, de l’isolement reproducteur et de l’hybridation. J’espère finir mes études d’ici l’automne 2018 pour ensuite trouver de nouveaux défis à relever avec les nouvelles connaissances acquises au cours des 7 dernières années !

Intérêts de recherche

Je suis particulièrement intéressé par tout ce qui touche de près ou de loin à la spéciation, plus précisément la spéciation hybride. Les différents mécanismes d’isolement reproducteur et comment ceux-ci influencent l’évolution des espèces par leur présence ou leur absence est aussi un sujet d’intérêt pour moi. En tant que microbiologiste j’adore aussi tout ce qui touche à l’écologie microbienne, notamment le rôle que pourraient avoir les interactions inter-espèces dans la spéciation. Bien sûr, mes recherches ne seraient rien sans la puissance des outils que j’utilise et reposant sur des principes de la microbiologie, la biologie moléculaire et la génétique. Aussi, j’adorerais découvrir de nouvelles espèces !

Publications

Wolters JF, Charron G, Gaspary A, Landry CR, Fiumera AC & Fiumera HI, Mitochondrial recombination reveals mito-mito epistasis in yeast. Genetics doi: 10.1534/genetics.117.300660 (2018)

Hénault M*, Eberlein C*, Charron G, Durand E, Nielly-Thibault L, Martin H & Landry CR, Yeast population genomics goes wild: the case of Saccharomyces paradoxus. In: Polz M, Rajora OP (eds) Population genomics: microorganisms. Springer, Cham (2017)

Leducq JB*, Henault M*, Charron G, Nielly-Thibault L, Terrat Y, Fiumera HL, Shapiro BJ & Landry CR, Mitochondrial recombination and introgression during speciation by hybridization. Molecular Biology and Evolution 34:1947-1959 (2017)

Eberlein C, Nielly-Thibault L, Maaroufi H, Dubé AK, Leducq JB, Charron G & Landry CR, The rapid evolution of an ohnolog contributes to the ecological specialization of incipient yeast species. Molecular Biology and Evolution 34:2173-2186 (2017)

Charron G & Landry CR, No evidence for extrinsic post-zygotic isolation in a wild Saccharomyces yeast system. Biology Letters 13:20170197 (2017)

Peris D, Moriarty RV, Alexander WG, Baker EC, Sylvester K, Sardi M, Langdon QK, Libkind D, Wang QM, Bai FY, Leducq JB, Charron G, Landry CR, Sampaio JP, Gonçalves P, Hyma KE, Fay JC, Sato TK & Hittinger CT, Hybridization and adaptive evolution of diverse Saccharomyces species for cellulosic biofuel production. Biotechnology for Biofuels 10:78 (2017)

Xia W, Nielly-Thibault L, Charron G, Landry CR, Kasimer D, Anderson JB & Kohn LM, Population genomics reveals structure at the individual, host-tree scale and persistence of genotypic variants of the undomesticated yeast Saccharomyces paradoxus in a natural woodland. Molecular Ecology 26:995–1007 (2017)

Filteau M, Charron G & Landry CR, Identification of the fitness determinants of budding yeast on a natural substrate. The ISME Journal 11:959–971 (2016)

Peris D, Langdon QK, Moriarty RV, Sylvester K, Bontrager M, Charron G, Leducq JB, Landry CR, Libkind D & Hittinger CT, Complex ancestries of lager-brewing hybrids were shaped by standing variation in the wild yeast Saccharomyces eubayanus. PLoS Genetics 12:e1006155 (2016)

Leducq JB, Nielly-Thibault L, Charron G, Eberlein C, Verta JP, Samani P, Sylvester K, Hittinger CT, Bell G & Landry CR, Speciation driven by hybridization and chromosomal plasticity in a wild yeast. Nature Microbiology 1:15003 (2016)

Freel K, Charron G, Leducq JB, Landry CR & Schacherer J, Lachancea quebecensis sp. nov., a yeast species consistently isolated from the tree bark in the Canadian province of Quebec. International Journal of Systematic and Evolutionary Microbiology 65:3392-3399 (2015)

Charron G*, Leducq JB* & Landry CR, Chromosomal variation segregates within incipient species and correlates with reproductive isolation. Molecular Ecology 23:4362-4372 (2014)

Leducq JB*, Charron G*, Samani P, Dubé AK, Sylvester K, James B, Almeida P, Sampaio JP, Hittinger CT, Bell G & Landry CR, Local climatic adaptation in a widespread microorganism. Proceedings of the Royal Society B 281:20132472 (2014)

Charron G, Leducq JB, Bertin C, Dubé AK & Landry CR, Exploring the northern limit of the distribution of Saccharomyces cerevisiae and Saccharomyces paradoxus in North America. FEMS Yeast Research 14:281-288 (2014)

Leducq JB, Charron G, Diss G, Gagnon-Arsenault I, Dubé AK & Landry CR, Evidence for the robustness of protein complexes to inter-species hybridization. PLoS Genetics 8:e1003161 (2012)